Pitolisant is a new agent for treating the excessive daytime sleepiness of narcolepsy that also helps cataplexy control by increasing histamine concentrations in the hypothalamus. Sodium oxybate is probably the most effective drug for severe cataplexy, taken before overnight sleep and once through the night its precise mechanism of action remains obscure. Narcolepsy is a lifelong sleep disorder that makes you feel overwhelmingly tired, and in severe cases. Antidepressant drug therapy at relatively low doses is the traditional treatment these most likely work through inhibiting REM sleep, predominantly by increasing brain monoamine concentrations. Examples include Bonjela, Blistex, or Cymex.
Cataplexy can be the most disabling symptom of the narcolepsy syndrome, severely limiting normal activities of daily living. A defining and enigmatic aspect is that certain emotional stimuli usually trigger the episodes. The semiology of cataplexy differs between adults and children. Cataplexy reflects the dysregulation of rapid-eye-movement (REM) sleep, such that REM-sleep atonia intrudes inappropriately into wakefulness as brief episodes of either focal or total paralysis of voluntary muscle. Drugs used to treat Cataplexy The following list of medications are in some way related to or used in the treatment of this condition. Remarkably and almost invariably, the clinical phenomenon of cataplexy results from the loss of around 40 000 hypocretin-containing neurones in the lateral hypothalamus in the context of narcolepsy type 1.
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